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The findings indicated that F9 significantly enhanced the safety profile compared to CA alone

The plasma level of N-methylisoleucine in MTX-responsive mice was significantly lower than that in nonresponsive mice, indicating its potential as a therapeutic biomarker (102)

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Their potential interactions with both hypothalamicpituitary pathways and peripheral metabolic markers continue to be evaluated, although the mechanistic basis of the blend remains an active area of study